Different types of cartilage neotissue fabricated from collagen hydrogels and mesenchymal stromal cells via SOX9, TGFB1 or BMP2 gene transfer.

Different types of cartilage neotissue fabricated from collagen hydrogels and mesenchymal stromal cells via SOX9, TGFB1 or BMP2 gene transfer.

OBJECTIVE:As native cartilage consists of different phenotypical zones, this study aims to fabricate different types of neocartilage constructs from collagen hydrogels and human mesenchymal stromal cells (MSCs) genetically modified to express different chondrogenic factors. DESIGN:Human MSCs derived...

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Bibliographic Details
Main Authors: Manuel Weißenberger, Manuela H Weißenberger, Mike Wagenbrenner, Tizian Heinz, Jenny Reboredo, Boris M Holzapfel, Maximilian Rudert, Jürgen Groll, Christopher H Evans, Andre F Steinert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0237479

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https://doi.org/10.1371/journal.pone.0237479

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