The SRG rat, a Sprague-Dawley Rag2/Il2rg double-knockout validated for human tumor oncology studies.

The SRG rat, a Sprague-Dawley Rag2/Il2rg double-knockout validated for human tumor oncology studies.

We have created the immunodeficient SRG rat, a Sprague-Dawley Rag2/Il2rg double knockout that lacks mature B cells, T cells, and circulating NK cells. This model has been tested and validated for use in oncology (SRG OncoRat®). The SRG rat demonstrates efficient tumor take rates and growth kinetics...

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Bibliographic Details
Main Authors: Fallon K Noto, Jaya Sangodkar, Bisoye Towobola Adedeji, Sam Moody, Christopher B McClain, Ming Tong, Eric Ostertag, Jack Crawford, Xiaohua Gao, Lauren Hurst, Caitlin M O'Connor, Erika N Hanson, Sudeh Izadmehr, Rita Tohmé, Jyothsna Narla, Kristin LeSueur, Kajari Bhattacharya, Amit Rupani, Marwan K Tayeh, Jeffrey W Innis, Matthew D Galsky, B Mark Evers, Analisa DiFeo, Goutham Narla, Tseten Y Jamling
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0240169

Internet

https://doi.org/10.1371/journal.pone.0240169

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