Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction

Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction

The primary function of pancreatic beta-cells is to produce and release insulin in response to increment in extracellular glucose concentrations, thus maintaining glucose homeostasis. Deficient beta-cell function can have profound metabolic consequences, leading to the development of hyperglycemia a...

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Main Authors: Alessandra Puddu, Roberta Sanguineti, François Mach, Franco Dallegri, Giorgio Luciano Viviani, Fabrizio Montecucco
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2013/750540
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spelling doaj-da437edb35f849e696bbbc595c39beb02020-11-25T00:04:37ZengHindawi LimitedMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/750540750540Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell DysfunctionAlessandra Puddu0Roberta Sanguineti1François Mach2Franco Dallegri3Giorgio Luciano Viviani4Fabrizio Montecucco5Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, 16132 Genova, ItalyDepartment of Internal Medicine, University of Genoa, Viale Benedetto XV 6, 16132 Genova, ItalyDivision of Cardiology, Geneva University Hospitals, Faculty of Medicine, Foundation for Medical Researches, Avenue de la Roseraie 64, 1211 Geneva 4, SwitzerlandFirst Medical Clinic, Laboratory of Phagocyte Physiopathology and Inflammation, Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, 16132 Genova, ItalyDepartment of Internal Medicine, University of Genoa, Viale Benedetto XV 6, 16132 Genova, ItalyDivision of Cardiology, Geneva University Hospitals, Faculty of Medicine, Foundation for Medical Researches, Avenue de la Roseraie 64, 1211 Geneva 4, SwitzerlandThe primary function of pancreatic beta-cells is to produce and release insulin in response to increment in extracellular glucose concentrations, thus maintaining glucose homeostasis. Deficient beta-cell function can have profound metabolic consequences, leading to the development of hyperglycemia and, ultimately, diabetes mellitus. Therefore, strategies targeting the maintenance of the normal function and protecting pancreatic beta-cells from injury or death might be crucial in the treatment of diabetes. This narrative review will update evidence from the recently identified molecular regulators preserving beta-cell mass and function recovery in order to suggest potential therapeutic targets against diabetes. This review will also highlight the relevance for novel molecular pathways potentially improving beta-cell dysfunction.http://dx.doi.org/10.1155/2013/750540
collection DOAJ
language English
format Article
sources DOAJ
author Alessandra Puddu
Roberta Sanguineti
François Mach
Franco Dallegri
Giorgio Luciano Viviani
Fabrizio Montecucco
spellingShingle Alessandra Puddu
Roberta Sanguineti
François Mach
Franco Dallegri
Giorgio Luciano Viviani
Fabrizio Montecucco
Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction
Mediators of Inflammation
author_facet Alessandra Puddu
Roberta Sanguineti
François Mach
Franco Dallegri
Giorgio Luciano Viviani
Fabrizio Montecucco
author_sort Alessandra Puddu
title Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction
title_short Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction
title_full Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction
title_fullStr Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction
title_full_unstemmed Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction
title_sort update on the protective molecular pathways improving pancreatic beta-cell dysfunction
publisher Hindawi Limited
series Mediators of Inflammation
issn 0962-9351
1466-1861
publishDate 2013-01-01
description The primary function of pancreatic beta-cells is to produce and release insulin in response to increment in extracellular glucose concentrations, thus maintaining glucose homeostasis. Deficient beta-cell function can have profound metabolic consequences, leading to the development of hyperglycemia and, ultimately, diabetes mellitus. Therefore, strategies targeting the maintenance of the normal function and protecting pancreatic beta-cells from injury or death might be crucial in the treatment of diabetes. This narrative review will update evidence from the recently identified molecular regulators preserving beta-cell mass and function recovery in order to suggest potential therapeutic targets against diabetes. This review will also highlight the relevance for novel molecular pathways potentially improving beta-cell dysfunction.
url http://dx.doi.org/10.1155/2013/750540
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AT robertasanguineti updateontheprotectivemolecularpathwaysimprovingpancreaticbetacelldysfunction
AT francoismach updateontheprotectivemolecularpathwaysimprovingpancreaticbetacelldysfunction
AT francodallegri updateontheprotectivemolecularpathwaysimprovingpancreaticbetacelldysfunction
AT giorgiolucianoviviani updateontheprotectivemolecularpathwaysimprovingpancreaticbetacelldysfunction
AT fabriziomontecucco updateontheprotectivemolecularpathwaysimprovingpancreaticbetacelldysfunction
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