Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1

Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1

UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug–drug interactions (DDIs), hyperbilirubinemia and drug-induced liver injury. This study aimed to investigate and compare the inhibitor...

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Bibliographic Details
Main Authors: Xuewei Cheng, Xia Lv, Hengyan Qu, Dandan Li, Mengmeng Hu, Wenzhi Guo, Guangbo Ge, Ruihua Dong
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Icotinib
Erlotinib
UGT1A1
Inhibitory effects
Drug–drug interactions (DDIs)
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383517301363

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http://www.sciencedirect.com/science/article/pii/S2211383517301363

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