Hypermethioninemia Leads to Fatal Bleeding and Increased Mortality in a Transgenic I278T Mouse Model of Homocystinuria

Hypermethioninemia Leads to Fatal Bleeding and Increased Mortality in a Transgenic I278T Mouse Model of Homocystinuria

Severely elevated plasma homocysteine and methionine lead to thromboembolic events and strokes in homocystinuric (HCU) patients. Mouse models of HCU failed to exhibit prothrombotic phenotype, presumably due to lack of hypermethioninemia. We evaluated the impact of hypermethioninemia together with hy...

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Bibliographic Details
Main Authors: Insun Park, Linda K. Johnson, Allaura Cox, Brian R. Branchford, Jorge Di Paola, Erez M. Bublil, Tomas Majtan
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Biomedicines
Subjects:
homocysteine
methionine intake
thrombosis
homocystinuria
coagulation factors
bleeding
Online Access:https://www.mdpi.com/2227-9059/8/8/244

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https://www.mdpi.com/2227-9059/8/8/244

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