Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory.
It is now established that vitamin A and its derivatives, retinoic acid (RA), are required for cognitive functions in adulthood. RA hyposignaling and hyperactivity of glucocorticoid (GC) pathway appear concomitantly during ageing and would contribute to the deterioration of hippocampal synaptic plas...
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doaj-da50231227294b8c87d2d49b536feadd2020-11-24T21:30:07ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652014-02-01610.3389/fnagi.2014.0000674719Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory.Damien eBonhomme0Damien eBonhomme1Véronique ePallet2Véronique ePallet3Gaelle eDominguez4Gaelle eDominguez5Laure eServant6Laure eServant7Nadia eHenkous8Pauline eLafenetre9Pauline eLafenetre10Paul eHigueret11Paul eHigueret12Daniel eBéracochéa13Katia eTouyarot14Katia eTouyarot15INRA, Nutrition et neurobiologie intégrée, UMR 1286Univ Bordeaux, Nutrition et neurobiologie intégrée, UMR 1286INRA, Nutrition et neurobiologie intégrée, UMR 1286Univ Bordeaux, Nutrition et neurobiologie intégrée, UMR 1286CNRS, INCIA, UMR 5287U-930, Inserm, Université François Rabelais, Parc GrandmontINRA, Nutrition et neurobiologie intégrée, UMR 1286Univ Bordeaux, Nutrition et neurobiologie intégrée, UMR 1286CNRS, INCIA, UMR 5287INRA, Nutrition et neurobiologie intégrée, UMR 1286Univ Bordeaux, Nutrition et neurobiologie intégrée, UMR 1286INRA, Nutrition et neurobiologie intégrée, UMR 1286Univ Bordeaux, Nutrition et neurobiologie intégrée, UMR 1286CNRS, INCIA, UMR 5287INRA, Nutrition et neurobiologie intégrée, UMR 1286Univ Bordeaux, Nutrition et neurobiologie intégrée, UMR 1286It is now established that vitamin A and its derivatives, retinoic acid (RA), are required for cognitive functions in adulthood. RA hyposignaling and hyperactivity of glucocorticoid (GC) pathway appear concomitantly during ageing and would contribute to the deterioration of hippocampal synaptic plasticity and functions. Furthermore, recent data have evidenced counteracting effects of retinoids on GC signaling pathway. In the present study, we addressed the following issue: whether the stimulation of RA pathway could modulate intrahippocampal corticosterone (CORT) levels in middle-aged mice and thereby impact on hippocampal plasticity and cognitive functions. We firstly investigated the effects of vitamin A supplementation and RA treatment in middle-aged mice, on contextual serial discrimination task (CSD), a paradigm which allows the detection of early signs of age-related hippocampal-dependent memory dysfunction. We then measured intrahippocampal CORT concentrations by microdialysis before and after a novelty-induced stress. Our results show that both RA treatment and vitamin A supplementation improve episodic-like memory in middle-aged mice but RA treatment appears to be more efficient. Moreover, we show that the beneficial effect of RA on memory is associated to an increase in hippocampal PSD-95 expression. In addition, intrahippocampal CORT levels are reduced after novelty-induced stress in RA treated animals. This effect cannot be related to a modulation of hippocampal 11β-HSD1 expression. In addition, RA treatment induces a modulation of retinoic acid receptors RARα and RARβ expression in middle-aged mice, a finding which has been correlated with the amplitude of intrahippocampal CORT levels after novelty-induced stress. Taken together, our results suggest that the preventive action of RA treatment on age-related memory deficits in middle-aged mice could be, at least in part, due to an inhibitory effect of retinoids on glucocorticoid activity.http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00006/fullCorticosteroneMemoryVitamin ARetinoic acidHippocampal plasticity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Damien eBonhomme Damien eBonhomme Véronique ePallet Véronique ePallet Gaelle eDominguez Gaelle eDominguez Laure eServant Laure eServant Nadia eHenkous Pauline eLafenetre Pauline eLafenetre Paul eHigueret Paul eHigueret Daniel eBéracochéa Katia eTouyarot Katia eTouyarot |
spellingShingle |
Damien eBonhomme Damien eBonhomme Véronique ePallet Véronique ePallet Gaelle eDominguez Gaelle eDominguez Laure eServant Laure eServant Nadia eHenkous Pauline eLafenetre Pauline eLafenetre Paul eHigueret Paul eHigueret Daniel eBéracochéa Katia eTouyarot Katia eTouyarot Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory. Frontiers in Aging Neuroscience Corticosterone Memory Vitamin A Retinoic acid Hippocampal plasticity |
author_facet |
Damien eBonhomme Damien eBonhomme Véronique ePallet Véronique ePallet Gaelle eDominguez Gaelle eDominguez Laure eServant Laure eServant Nadia eHenkous Pauline eLafenetre Pauline eLafenetre Paul eHigueret Paul eHigueret Daniel eBéracochéa Katia eTouyarot Katia eTouyarot |
author_sort |
Damien eBonhomme |
title |
Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory. |
title_short |
Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory. |
title_full |
Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory. |
title_fullStr |
Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory. |
title_full_unstemmed |
Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory. |
title_sort |
retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory. |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2014-02-01 |
description |
It is now established that vitamin A and its derivatives, retinoic acid (RA), are required for cognitive functions in adulthood. RA hyposignaling and hyperactivity of glucocorticoid (GC) pathway appear concomitantly during ageing and would contribute to the deterioration of hippocampal synaptic plasticity and functions. Furthermore, recent data have evidenced counteracting effects of retinoids on GC signaling pathway. In the present study, we addressed the following issue: whether the stimulation of RA pathway could modulate intrahippocampal corticosterone (CORT) levels in middle-aged mice and thereby impact on hippocampal plasticity and cognitive functions. We firstly investigated the effects of vitamin A supplementation and RA treatment in middle-aged mice, on contextual serial discrimination task (CSD), a paradigm which allows the detection of early signs of age-related hippocampal-dependent memory dysfunction. We then measured intrahippocampal CORT concentrations by microdialysis before and after a novelty-induced stress. Our results show that both RA treatment and vitamin A supplementation improve episodic-like memory in middle-aged mice but RA treatment appears to be more efficient. Moreover, we show that the beneficial effect of RA on memory is associated to an increase in hippocampal PSD-95 expression. In addition, intrahippocampal CORT levels are reduced after novelty-induced stress in RA treated animals. This effect cannot be related to a modulation of hippocampal 11β-HSD1 expression. In addition, RA treatment induces a modulation of retinoic acid receptors RARα and RARβ expression in middle-aged mice, a finding which has been correlated with the amplitude of intrahippocampal CORT levels after novelty-induced stress. Taken together, our results suggest that the preventive action of RA treatment on age-related memory deficits in middle-aged mice could be, at least in part, due to an inhibitory effect of retinoids on glucocorticoid activity. |
topic |
Corticosterone Memory Vitamin A Retinoic acid Hippocampal plasticity |
url |
http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00006/full |
work_keys_str_mv |
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