GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Attenuates Cerebral Ischemia Injury In Vivo and Vitro by Differential Modulations of NMDA Receptors Subunit Components at Different Post-Ischemia Stage in Mice

GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Attenuates Cerebral Ischemia Injury In Vivo and Vitro by Differential Modulations of NMDA Receptors Subunit Components at Different Post-Ischemia Stage in Mice

Excessive activation of NMDA receptors (NMDARs) is implicated in pathological synaptic plasticity also known as post-ischemic long-term potentiation (i-LTP) which was produced by glutamate mediated excitotoxicity after stroke. In the past decades, many NMDARs inhibitors failed in clinical investigat...

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Bibliographic Details
Main Authors: Chen Zheng, Zhi H. Qiao, Meng Z. Hou, Nan N. Liu, Bin Fu, Ran Ding, Yuan Y. Li, Liang P. Wei, Ai L. Liu, Hui Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
transient middle cerebral artery occlusion
oxygen-glucose deprivation
ischemia
pathological synaptic plasticity
GLYX-13
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00186/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2017.00186/full

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