Blockage of Store-Operated Ca<sup>2+</sup> Influx by Synta66 is Mediated by Direct Inhibition of the Ca<sup>2+</sup> Selective Orai1 Pore

Blockage of Store-Operated Ca<sup>2+</sup> Influx by Synta66 is Mediated by Direct Inhibition of the Ca<sup>2+</sup> Selective Orai1 Pore

The Ca<sup>2+</sup> sensor STIM1 and the Ca<sup>2+</sup> channel Orai1 that form the store-operated Ca<sup>2+</sup> (SOC) channel complex are key targets for drug development. Selective SOC inhibitors are currently undergoing clinical evaluation for the treatment...

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Bibliographic Details
Main Authors: Linda Waldherr, Adela Tiffner, Deepti Mishra, Matthias Sallinger, Romana Schober, Irene Frischauf, Tony Schmidt, Verena Handl, Peter Sagmeister, Manuel Köckinger, Isabella Derler, Muammer Üçal, Daniel Bonhenry, Silke Patz, Rainer Schindl
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
STIM
Orai
Ca<sup>2+</sup>, SOCE
Synta66
pore
binding
Online Access:https://www.mdpi.com/2072-6694/12/10/2876

Internet

https://www.mdpi.com/2072-6694/12/10/2876

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