Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage

Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage

G protein-coupled receptor (GPCR) kinase 2 (GRK2) regulates cellular signaling via desensitization of GPCRs and by direct interaction with intracellular signaling molecules. We recently described that ischemic brain injury decreases cerebral GRK2 levels. Here we studied the effect of astrocyte GRK2-...

Full description

Bibliographic Details
Main Authors: Cora H. Nijboer, Cobi J. Heijnen, Vincent Degos, Hanneke L.D.M. Willemen, Pierre Gressens, Annemieke Kavelaars
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neurobiology of Disease
Subjects:
Ischemic brain injury
Neuroprotection
Astrocytes
G protein-coupled receptor kinase 2 (GRK2)
Excitotoxicity
Glutamate transporter GLAST
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000041

Internet

http://www.sciencedirect.com/science/article/pii/S0969996113000041

Similar Items