Aging and replicative senescence have related effects on human stem and progenitor cells.

Aging and replicative senescence have related effects on human stem and progenitor cells.

The regenerative potential diminishes with age and this has been ascribed to functional impairments of adult stem cells. Cells in culture undergo senescence after a certain number of cell divisions whereby the cells enlarge and finally stop proliferation. This observation of replicative senescence h...

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Bibliographic Details
Main Authors: Wolfgang Wagner, Simone Bork, Patrick Horn, Damir Krunic, Thomas Walenda, Anke Diehlmann, Vladimir Benes, Jonathon Blake, Franz-Xaver Huber, Volker Eckstein, Petra Boukamp, Anthony D Ho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2688074?pdf=render

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http://europepmc.org/articles/PMC2688074?pdf=render

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