A glycine zipper motif mediates the formation of toxic β-amyloid oligomers <it>in vitro </it>and <it>in vivo</it>

A glycine zipper motif mediates the formation of toxic β-amyloid oligomers <it>in vitro </it>and <it>in vivo</it>

<p>Abstract</p> <p>Background</p> <p>The β-amyloid peptide (Aβ) contains a Gly-XXX-Gly-XXX-Gly motif in its C-terminal region that has been proposed to form a "glycine zipper" that drives the formation of toxic Aβ oligomers. We have tested this hypothesis by e...

Full description

Bibliographic Details
Main Authors: Fan Emily Y, Dingwell Natalie, Magrane Jordi, Lacor Pascale, Gonzales Patrick, Roberts Christine M, Dostal Vishantie, Fonte Virginia, Silverman Michael A, Stein Gretchen H, Link Christopher D
Format: Article
Language:English
Published: BMC 2011-08-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer's disease
<it>C. elegans</it>
pore-forming toxin
glycine motif
Online Access:http://www.molecularneurodegeneration.com/content/6/1/61

Internet

http://www.molecularneurodegeneration.com/content/6/1/61

Similar Items