Diallyl thiosulfinate enhanced the anti-cancer activity of dexamethasone in the side population cells of multiple myeloma by promoting miR-127-3p and deactivating the PI3K/AKT signaling pathway

Diallyl thiosulfinate enhanced the anti-cancer activity of dexamethasone in the side population cells of multiple myeloma by promoting miR-127-3p and deactivating the PI3K/AKT signaling pathway

Abstract Background Side population (SP) cells, which have similar features to those of cancer stem cells, show resistance to dexamethasone (Dex) treatment. Thus, new drugs that can be used in combination with Dex to reduce the population of SP cells in multiple myeloma (MM) are required. Diallyl th...

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Bibliographic Details
Main Authors: Wenfeng He, Yonghui Fu, Yongliang Zheng, Xiaoping Wang, Bin Liu, Junquan Zeng
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Cancer
Subjects:
Multiple myeloma
Side population cells
Diallyl trisulfide
Dexamethasone
miR-127-3p
PI3K signaling pathway
Online Access:https://doi.org/10.1186/s12885-021-07833-5

Internet

https://doi.org/10.1186/s12885-021-07833-5

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