Induction of colorectal carcinogenesis in the C57BL/6J and A/J mouse strains with a reduced DSS dose in the AOM/DSS model

Induction of colorectal carcinogenesis in the C57BL/6J and A/J mouse strains with a reduced DSS dose in the AOM/DSS model

Abstract Background Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide and thus mouse models of CRC are of significant value to study the pathogenesis. The Azoxymethane/Dextran sulfate sodium (AOM/DSS) model is a widely used, robust initiation-promotion model for chemi...

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Bibliographic Details
Main Authors: Henriette Arnesen, Mette Helen Bjørge Müller, Mona Aleksandersen, Gunn Charlotte Østby, Harald Carlsen, Jan Erik Paulsen, Preben Boysen
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Laboratory Animal Research
Subjects:
AOM/DSS
Colorectal cancer
Mouse models
Disease models
Azoxymethane
Dextran sulfate sodium
Online Access:https://doi.org/10.1186/s42826-021-00096-y

Internet

https://doi.org/10.1186/s42826-021-00096-y

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