Multiplex quantitative analysis of cancer-associated fibroblasts and immunotherapy outcome in metastatic melanoma

Multiplex quantitative analysis of cancer-associated fibroblasts and immunotherapy outcome in metastatic melanoma

Abstract Background The cancer-associated fibroblast (CAF) population is implicated in immune dysregulation. Here, we test the hypothesis that CAF profiles in pretreatment tumor specimens are associated with response to immune checkpoint blockade of programmed cell death 1 (PD-1). Methods Pretreatme...

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Bibliographic Details
Main Authors: Pok Fai Wong, Wei Wei, Swati Gupta, James W. Smithy, Daniel Zelterman, Harriet M. Kluger, David L. Rimm
Format: Article
Language:English
Published: BMJ Publishing Group 2019-07-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Biomarkers
Cancer-associated fibroblasts
Fibroblast activation protein
Immunotherapy
Melanoma
PD-1
Online Access:http://link.springer.com/article/10.1186/s40425-019-0675-0

Internet

http://link.springer.com/article/10.1186/s40425-019-0675-0

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