Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation
The influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial design 3². Gastrointestinal tolerance following oral administration in rats...
Main Authors: | Beck Ruy Carlos R., Haas Sandra Elisa, Guterres Silvia Stanisçuaski, Ré Maria Inês, Benvenutti Edilson V., Pohlmann Adriana Raffin |
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Format: | Article |
Language: | English |
Published: |
Sociedade Brasileira de Química
2006-01-01
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Series: | Química Nova |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000500019 |
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