The Effect of Neddylation Inhibition on Inflammation-Induced MMP9 Gene Expression in Esophageal Squamous Cell Carcinoma

The Effect of Neddylation Inhibition on Inflammation-Induced MMP9 Gene Expression in Esophageal Squamous Cell Carcinoma

Inhibition of the protein neddylation process by the small-molecule inhibitor MLN4924 has been recently indicated as a promising direction for cancer treatment. However, the knowledge of all biological consequences of MLN4924 for cancer cells is still incomplete. Here, we report that MLN4924 inhibit...

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Bibliographic Details
Main Authors: Anita Hryniewicz-Jankowska, Jaroslaw Wierzbicki, Renata Tabola, Kamilla Stach, Khalid Sossey-Alaoui, Katarzyna Augoff
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
neddylation
metalloproteinases
cancer cell migration
TNF-α–NFκB signaling pathway
esophageal squamous cell carcinoma
Online Access:https://www.mdpi.com/1422-0067/22/4/1716

Internet

https://www.mdpi.com/1422-0067/22/4/1716

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