Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis

Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis

Primary biliary cirrhosis (PBC) is an uncommon autoimmune disease with a homogeneous clinical phenotype that reflects incomplete disease concordance in monozygotic (MZ) twins. We have taken advantage of a unique collection consisting of genomic DNA and mRNA from peripheral blood cells of female MZ t...

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Bibliographic Details
Main Authors: Carlo eSelmi, Francesca eCavaciocchi, Ana eLleo, Cristina eCheroni, Raffaele eDe Francesco, Simone A. Lombardi, Maria eDe Santis, Francesca eMeda, Maria Gabriella eRaimondo, Chiara eCrotti, Marco eFolci, Luca eZammataro, Marlyn J. Mayo, Nancy eBach, Shinji eShimoda, Stuart eGordon, Monica eMiozzo, Pietro eInvernizzi, Mauro ePodda, Rossana eScavelli, Michelle R. Martin, Michael Forrest Seldin, Janine M. LaSalle, M. Eric eGershwin
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Immunology
Subjects:
Twins, Monozygotic
epigenetics
primary biliary cirrhosis
environment
Autoimmune cholangitis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00128/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00128/full

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