A Clickable Oxysterol Photolabel Retains NMDA Receptor Activity and Accumulates in Neurons

A Clickable Oxysterol Photolabel Retains NMDA Receptor Activity and Accumulates in Neurons

Oxysterol analogs that modulate NMDA receptor function are candidates for therapeutic development to treat neuropsychiatric disorders. However, the cellular actions of these compounds are still unclear. For instance, how these compounds are compartmentalized or trafficked in neurons is unknown. In t...

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Bibliographic Details
Main Authors: Daniel M. Chen, Luke Ziolkowski, Ann Benz, Mingxing Qian, Charles F. Zorumski, Douglas F. Covey, Steven Mennerick
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Neuroscience
Subjects:
NMDA receptor
oxysterol
photolabel
click chemistry
modulation
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00923/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00923/full

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