Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection

Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection

Summary: The immunometabolic mechanisms underlying suboptimal T cell immunity in tuberculosis remain undefined. Here, we examine how chronic Mycobacterium tuberculosis (Mtb) and M. bovis BCG infections rewire metabolic circuits and alter effector functions in lung CD8+ T cells. As Mtb infection prog...

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Bibliographic Details
Main Authors: Shannon L. Russell, Dirk A. Lamprecht, Tawanda Mandizvo, Terrence T. Jones, Vanessa Naidoo, Kelvin W. Addicott, Chivonne Moodley, Bongani Ngcobo, David K. Crossman, Gordon Wells, Adrie J.C. Steyn
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719315165

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http://www.sciencedirect.com/science/article/pii/S2211124719315165

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