Synthesis, Structural Studies and Molecular Modelling of a Novel Imidazoline Derivative with Antifungal Activity

Synthesis, Structural Studies and Molecular Modelling of a Novel Imidazoline Derivative with Antifungal Activity

Six novel imidazoline derivatives were synthesized and tested in antifungal assays. One of the compounds, N-cyclohexyl-2-imino-3-(4-nitrophenyl)imidazolidine-1-carboxamide showed moderate activity against several clinical strains of Candida albicans. Its structure was solved by X-ray crystallography...

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Bibliographic Details
Main Authors: Tomasz M. Wróbel, Urszula Kosikowska, Agnieszka A. Kaczor, Sylwia Andrzejczuk, Zbigniew Karczmarzyk, Waldemar Wysocki, Zofia Urbańczyk-Lipkowska, Maja Morawiak, Dariusz Matosiuk
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Molecules
Subjects:
antifungal
Candida albicans
X-ray analysis
14-α-sterol demethylase
molecular modelling
synthesis
Online Access:http://www.mdpi.com/1420-3049/20/8/14761

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http://www.mdpi.com/1420-3049/20/8/14761

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