Inhibition of Rho Activity Increases Expression of SaeRS-Dependent Virulence Factor Genes in Staphylococcus aureus, Showing a Link between Transcription Termination, Antibiotic Action, and Virulence

Inhibition of Rho Activity Increases Expression of SaeRS-Dependent Virulence Factor Genes in Staphylococcus aureus, Showing a Link between Transcription Termination, Antibiotic Action, and Virulence

The major human pathogen Staphylococcus aureus is a widespread commensal bacterium but also the most common cause of nosocomial infections. It adapts to the different host niches through a complex gene regulatory network. We show here that the Rho transcription termination factor, which represses pe...

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Bibliographic Details
Main Authors: Anna Nagel, Stephan Michalik, Michel Debarbouille, Tobias Hertlein, Manuela Gesell Salazar, Hermann Rath, Tarek Msadek, Knut Ohlsen, Jan Maarten van Dijl, Uwe Völker, Ulrike Mäder
Format: Article
Language:English
Published: American Society for Microbiology 2018-09-01
Series:mBio
Subjects:
SaeRS TCS
Staphylococcus aureus
antisense transcription
bicyclomycin
proteome
transcription termination
Online Access:https://doi.org/10.1128/mBio.01332-18

Internet

https://doi.org/10.1128/mBio.01332-18

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