Rheb1-Deficient Neutrophils Promote Hematopoietic Stem/Progenitor Cell Proliferation via Mesenchymal Stem Cells

Rheb1-Deficient Neutrophils Promote Hematopoietic Stem/Progenitor Cell Proliferation via Mesenchymal Stem Cells

Myeloid cells have been identified as hematopoietic stem cell (HSC)-regulating cells. However, the mechanisms by which myeloid cells regulate the function of HSCs are not fully defined. Our previous study indicated that the HSCs are over-expanded in Vav1-Cre;Rheb1fl/fl mice. Here, using in vivo and...

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Bibliographic Details
Main Authors: Juan Gao, Shuaibing Hou, Shengnan Yuan, Yuxia Wang, Yanan Gao, Xiaolu Sun, Weili Wang, Yajing Chu, Yuan Zhou, Xiaoming Feng, Hongbo R. Luo, Tao Cheng, Jun Shi, Weiping Yuan, Xiaomin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Rheb1-deficient neutrophils
hematopoietic stem/progenitor cell
proliferation
mesenchymal stem cells
IL-6
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.650599/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.650599/full

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