Lipidomic and transcriptional analysis of the linoleoyl-omega-hydroxyceramide biosynthetic pathway in human psoriatic lesions

Lipidomic and transcriptional analysis of the linoleoyl-omega-hydroxyceramide biosynthetic pathway in human psoriatic lesions

A complex assembly of lipids including fatty acids, cholesterol, and ceramides is vital to the integrity of the mammalian epidermal barrier. The formation of this barrier requires oxidation of the substrate fatty acid, linoleic acid (LA), which is initiated by the enzyme 12R-lipoxygenase (LOX). In t...

Full description

Bibliographic Details
Main Authors: Victoria J. Tyrrell, Faraz Ali, William E. Boeglin, Robert Andrews, James Burston, James C. Birchall, John R. Ingram, Robert C. Murphy, Vincent Piguet, Alan R. Brash, Valerie B. O'Donnell, Christopher P. Thomas
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Lipid Research
Subjects:
ceramides
clinical lipidology
epidermis
lipid metabolism in the skin
lipids/oxidation
lipoxygenase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227521000766

Internet

http://www.sciencedirect.com/science/article/pii/S0022227521000766

Similar Items