Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling

Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling

Mitochondrial uncoupling is implicated in many patho(physiological) states. Using confocal live cell imaging and an optical O2 sensing technique, we show that moderate uncoupling of the mitochondria with plecomacrolide Baf (bafilomycin A1) causes partial depolarization of the mitochondria and deep s...

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Bibliographic Details
Main Authors: Alexander V. Zhdanov, Ruslan I. Dmitriev, Dmitri B. Papkovsky
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2012-10-01
Series:Bioscience Reports
Subjects:
bafilomycin A1
bioenergetics
hypoxia inducible factor
intracellular oxygen
mitochondrial function
respiration
Online Access:http://www.bioscirep.org/bsr/032/0587/bsr0320587.htm

Internet

http://www.bioscirep.org/bsr/032/0587/bsr0320587.htm

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