Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression.

Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression.

AIMS: Stimulated release of tissue-type plasminogen activator (t-PA) is pivotal for an intravascular fibrinolytic response and protects the circulation from occluding thrombosis. Hence, an impaired t-PA production is associated with increased risk for atherothrombotic events. A pharmacological means...

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Bibliographic Details
Main Authors: Pia Larsson, Erik Ulfhammer, Mia Magnusson, Niklas Bergh, Sebastian Lunke, Assam El-Osta, Robert L Medcalf, Per-Arne Svensson, Lena Karlsson, Sverker Jern
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3282745?pdf=render

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http://europepmc.org/articles/PMC3282745?pdf=render

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