The Increased Densities, But Different Distributions, of Both C3 and S100A10 Immunopositive Astrocyte-Like Cells in Alzheimer’s Disease Brains Suggest Possible Roles for Both A1 and A2 Astrocytes in the Disease Pathogenesis

The Increased Densities, But Different Distributions, of Both C3 and S100A10 Immunopositive Astrocyte-Like Cells in Alzheimer’s Disease Brains Suggest Possible Roles for Both A1 and A2 Astrocytes in the Disease Pathogenesis

There is increasing evidence of astrocyte dysfunction in the pathogenesis of Alzheimer’s disease (AD). Animal studies supported by human post-mortem work have demonstrated two main astrocyte types: the C3 immunopositive neurotoxic A1 astrocytes and the S100A10 immunopositive neuroprotective A2 astro...

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Bibliographic Details
Main Authors: Andrew King, Boglarka Szekely, Eda Calapkulu, Hanan Ali, Francesca Rios, Shalmai Jones, Claire Troakes
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Brain Sciences
Subjects:
Alzheimer’s
dementia
immunohistochemistry
A1
A2
astrocytes
Online Access:https://www.mdpi.com/2076-3425/10/8/503

Internet

https://www.mdpi.com/2076-3425/10/8/503

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