Discovery and confirmation of ligand binding specificities of the Schistosoma japonicum polarity protein Scribble.

BACKGROUND: Schistosomiasis is a chronic debilitating parasitic disease that afflicts more than 200 million individuals worldwide. Long-term administration of chemotherapy with the single available drug, praziquantel, has led to growing concerns about drug resistance. The PSD-95/Dlg/ZO-1 (PDZ) domai...

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Bibliographic Details
Main Authors: Pengfei Cai, Yi Mu, Xianyu Piao, Nan Hou, Shuai Liu, Youhe Gao, Heng Wang, Qijun Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4006718?pdf=render