SQSTM1L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells

SQSTM1L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are genetically, pathologically and clinically-related progressive neurodegenerative diseases. Thus far, several SQSTM1 variations have been identified in patients with ALS and FTD. However, it remains unclear how SQSTM1 variation...

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Bibliographic Details
Main Authors: Masahisa Nozaki, Asako Otomo, Shun Mitsui, Suzuka Ono, Ryohei Shirakawa, YongPing Chen, Yutaro Hama, Kai Sato, XuePing Chen, Toshiyasu Suzuki, Hui-Fang Shang, Shinji Hadano
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:eNeurologicalSci
Subjects:
Amyotrophic lateral sclerosis (ALS)
Frontotemporal dementia (FTD)
SQSTM1
SQSTM1/p62-body
MAP1LC3/LC3
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2405650220300800

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http://www.sciencedirect.com/science/article/pii/S2405650220300800

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