N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain

N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain

Abstract Intraneuronal insoluble inclusions made of Tau protein are neuropathological hallmarks of Alzheimer Disease (AD). Cleavage of Tau by legumain (LGMN) has been proposed to be crucial for aggregation of Tau into fibrils. However, it remains unclear if LGMN-cleaved Tau fragments accumulate in A...

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Bibliographic Details
Main Authors: Kerstin Schlegel, Khader Awwad, Roland G. Heym, David Holzinger, Annika Doell, Stefan Barghorn, Thomas R. Jahn, Corinna Klein, Yulia Mordashova, Michael Schulz, Laura Gasparini
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Acta Neuropathologica Communications
Subjects:
Tau protease
Tau truncation
Insoluble Tau
Alzheimer disease
Online Access:http://link.springer.com/article/10.1186/s40478-019-0831-2

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http://link.springer.com/article/10.1186/s40478-019-0831-2

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