Distinct Immune Profiles of Exhausted Effector and Memory CD8+ T Cells in Individuals With Filarial Lymphedema

Distinct Immune Profiles of Exhausted Effector and Memory CD8+ T Cells in Individuals With Filarial Lymphedema

CD8+ T cells are crucial for the clearance of viral infections, and current research begins to highlight their importance in parasitic diseases too. In-depth research about characteristics of CD8+ T-cell subsets and exhaustion remains uncertain, especially during filariasis, a chronic helminth infec...

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Bibliographic Details
Main Authors: Sacha Horn, Dennis Borrero-Wolff, Manuel Ritter, Kathrin Arndts, Anna Wiszniewsky, Linda Batsa Debrah, Alexander Y. Debrah, Jubin Osei-Mensah, Mkunde Chachage, Achim Hoerauf, Inge Kroidl, Laura E. Layland
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Filariae
CD8+ T cell exhaustion
Wuchereria bancrofti infection
lymphatic filariasis
immune modulation
lymphedema
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.680832/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.680832/full

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