Soluble St2 Induces Cardiac Fibroblast Activation and Collagen Synthesis via Neuropilin-1

Soluble St2 Induces Cardiac Fibroblast Activation and Collagen Synthesis via Neuropilin-1

Circulating levels of soluble interleukin 1 receptor-like 1 (sST2) are increased in heart failure and associated with poor outcome, likely because of the activation of inflammation and fibrosis. We investigated the pathogenic role of sST2 as an inductor of cardiac fibroblasts activation and collagen...

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Bibliographic Details
Main Authors: Lara Matilla, Vanessa Arrieta, Eva Jover, Amaia Garcia-Peña, Ernesto Martinez-Martinez, Rafael Sadaba, Virginia Alvarez, Adela Navarro, Amaya Fernandez-Celis, Alicia Gainza, Enrique Santamaria, Joaquín Fernandez-Irigoyen, Patrick Rossignol, Faiez Zannad, Natalia Lopez-Andres
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
sST2
neuropilin-1
collagen
fibroblast activation
NF-κB
Online Access:https://www.mdpi.com/2073-4409/9/7/1667

Internet

https://www.mdpi.com/2073-4409/9/7/1667

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