Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa

Pseudomonas aeruginosa has been highlighted by the recent WHO Global Priority Pathogen List due to multidrug resistance. Without new antibiotics, polymyxins remain a last-line therapeutic option for this difficult-to-treat pathogen. The emergence of polymyxin resistance highlights the growing threat...

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Bibliographic Details
Main Authors: Mei-Ling Han, Yan Zhu, Darren J. Creek, Yu-Wei Lin, Alina D. Gutu, Paul Hertzog, Tony Purcell, Hsin-Hui Shen, Samuel M. Moskowitz, Tony Velkov, Jian Li
Format: Article
Language:English
Published: American Society for Microbiology 2019-01-01
Series:mSystems
Subjects:
lipid A modification
metabolomics
Pseudomonas aeruginosa
transcriptomics
glycerophospholipids
lipopolysaccharide
polymyxins
Online Access:https://doi.org/10.1128/mSystems.00149-18

Internet

https://doi.org/10.1128/mSystems.00149-18

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