Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

Cancer-associated fibroblasts (CAFs) are a major cellular component of tumor microenvironment in most solid cancers. Altered cellular metabolism is a hallmark of cancer, and much of the published literature has focused on neoplastic cell-autonomous processes for these adaptations. We demonstrate tha...

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Bibliographic Details
Main Authors: Hongyun Zhao, Lifeng Yang, Joelle Baddour, Abhinav Achreja, Vincent Bernard, Tyler Moss, Juan C Marini, Thavisha Tudawe, Elena G Seviour, F Anthony San Lucas, Hector Alvarez, Sonal Gupta, Sourindra N Maiti, Laurence Cooper, Donna Peehl, Prahlad T Ram, Anirban Maitra, Deepak Nagrath
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
cancer metabolism
tumor microenvironment
exosomes
metabolic flux analysis
reductive carboxylation
macropinocytosis
Online Access:https://elifesciences.org/articles/10250

Internet

https://elifesciences.org/articles/10250

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