Galectin-3 in Prostate Cancer Stem-Like Cells Is Immunosuppressive and Drives Early Metastasis

Galectin-3 in Prostate Cancer Stem-Like Cells Is Immunosuppressive and Drives Early Metastasis

Galectin-3 (Gal-3) is an extracellular matrix glycan-binding protein with several immunosuppressive and pro-tumor functions. The role of Galectin-3 in cancer stem-like cells (CSCs) is poorly investigated. Here, we show that prostate CSCs also colonizing prostate-draining lymph nodes of transgenic ad...

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Bibliographic Details
Main Authors: Sara Caputo, Matteo Grioni, Chiara S. Brambillasca, Antonella Monno, Arianna Brevi, Massimo Freschi, Ignazio S. Piras, Angela R. Elia, Valentina Pieri, Tania Baccega, Angelo Lombardo, Rossella Galli, Alberto Briganti, Claudio Doglioni, Elena Jachetti, Matteo Bellone
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
prostate cancer
cancer stem cell
Galectin-3
immunosuppression
immune surveillance
prostate intraepithelial neoplasia
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01820/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01820/full

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