Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2

Abstract AMP-activated protein kinase (AMPK) is a pivotal cellular energy sensor. It is activated by stresses that cause depletion of energy and initiates adaptive responses by regulating metabolism balance. AMPK forms αβγ heterotrimer. In fission yeast, activation of AMPK mainly depends on the phos...

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Bibliographic Details
Main Authors: Yongyi Chen, Xiaoyue Hu, Chao Guo, Yao Yu, Hong Lu
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03442-0