An MRTF-A–Sp1–PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy

An MRTF-A–Sp1–PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy

Cardiac hypertrophy is a critical intermediate step in the pathogenesis of heart failure. A myriad of signaling networks converge on cardiomyocytes to elicit hypertrophic growth in response to various injurious stimuli. In the present study, we investigated the cardiomyocyte-specific role of myocard...

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Bibliographic Details
Main Authors: Teng Wu, Huidi Wang, Xiaojun Xin, Jie Yang, Yannan Hou, Mingming Fang, Xiang Lu, Yong Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cardiac hypertrophy
cardiomyocyte
transcriptional regulation
angiotensin II
MRTF-A
Sp1
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00839/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00839/full

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