Human Autoantibodies Against N-Methyl-D-Aspartate Receptor Modestly Alter Dopamine D1 Receptor Surface Dynamics

Human Autoantibodies Against N-Methyl-D-Aspartate Receptor Modestly Alter Dopamine D1 Receptor Surface Dynamics

Circulating autoantibodies directed against extracellular domains of the glutamatergic N-methyl-D-aspartate receptors (NMDAR-Ab) elicit psychotic symptoms in humans and behavioral deficits in animal models. Recent advances suggest that NMDAR-Ab exert their pathogenic action by altering the trafficki...

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Bibliographic Details
Main Authors: Hélène Gréa, Delphine Bouchet, Véronique Rogemond, Nora Hamdani, Emmanuel Le Guen, Ryad Tamouza, Estelle Darrau, Christine Passerieux, Jérôme Honnorat, Marion Leboyer, Laurent Groc
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Psychiatry
Subjects:
autoimmunity
encephalitis
schizophrenia
autoimmune psychosis
dopamine
single molecule imaging
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2019.00670/full

Internet

https://www.frontiersin.org/article/10.3389/fpsyt.2019.00670/full

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