The Nuclear Lamina: Protein Accumulation and Disease

The Nuclear Lamina: Protein Accumulation and Disease

Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging. One proteinaceous structure underlying the nuclear e...

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Bibliographic Details
Main Authors: Carla Almendáriz-Palacios, Zoe E. Gillespie, Matthew Janzen, Valeria Martinez, Joanna M. Bridger, Troy A. A. Harkness, Darrell D. Mousseau, Christopher H. Eskiw
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Biomedicines
Subjects:
lamina
protein accumulation
premature aging
neurodegeneration
autophagy
clearance
Online Access:https://www.mdpi.com/2227-9059/8/7/188

Internet

https://www.mdpi.com/2227-9059/8/7/188

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