Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

Neuronal activity is known to increase myelination by oligodendrocytes in the mouse brain. Here, Mitew et al. demonstrate that chemogenetic manipulations of somatosensory axon activity both increase the generation of new oligodendrocytes and preferentially enhance myelination of the activated axons.

Bibliographic Details
Main Authors: Stanislaw Mitew, Ilan Gobius, Laura R. Fenlon, Stuart J. McDougall, David Hawkes, Yao Lulu Xing, Helena Bujalka, Andrew L. Gundlach, Linda J. Richards, Trevor J. Kilpatrick, Tobias D. Merson, Ben Emery
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02719-2

Internet

https://doi.org/10.1038/s41467-017-02719-2

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