Septin4 promotes cardiomyocytes apoptosis by enhancing the VHL-mediated degradation of HIF-1α
Abstract Septin4, a protein localized at mitochondrion, can promote cells apoptosis mainly by binding XIAP (X-linked inhibitors of apoptosis), however, nothing is known about the role and mechanism of Septin4 in cardiomyocytes apoptosis. Here in the current study, we report that HIF-1α (hypoxia-indu...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-07-01
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Series: | Cell Death Discovery |
Online Access: | https://doi.org/10.1038/s41420-021-00563-4 |