Septin4 promotes cardiomyocytes apoptosis by enhancing the VHL-mediated degradation of HIF-1α

Abstract Septin4, a protein localized at mitochondrion, can promote cells apoptosis mainly by binding XIAP (X-linked inhibitors of apoptosis), however, nothing is known about the role and mechanism of Septin4 in cardiomyocytes apoptosis. Here in the current study, we report that HIF-1α (hypoxia-indu...

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Bibliographic Details
Main Authors: Shaojun Wu, Ying Zhang, Shilong You, Saien Lu, Naijin Zhang, Yingxian Sun
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00563-4