Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
Mitochondrial dysfunction occurs in Parkinson's disease, although the underlying mechanisms are unclear. Here, the authors find necdin works to stabilise the mitochondrial regulator PGC-1α, and that overexpression of necdin protects against MPTP-mediated neurodegeneration both in vitro and in v...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10943 |