Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments

Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments

At inflammatory sites, ectopic lymphoid-like structures (ELS) can be induced through the function of chemokine CXCL13 produced by CD4+ T cells. Here the authors show that a transcription factor, Sox4, induces the expression of CXCL13 in CD4 T cells in vitro, and is associated with ELS formation in p...

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Bibliographic Details
Main Authors: Hiroyuki Yoshitomi, Shio Kobayashi, Aya Miyagawa-Hayashino, Akinori Okahata, Kohei Doi, Kohei Nishitani, Koichi Murata, Hiromu Ito, Tatsuaki Tsuruyama, Hironori Haga, Shuichi Matsuda, Junya Toguchida
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06187-0

Internet

https://doi.org/10.1038/s41467-018-06187-0

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