Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α

Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α

Pathological oxygen deprivation inhibits prolyl hydroxylase (PHD) activity and stimulates a protective cellular oxygen-sensing response in part through the stabilization and activation of the Hypoxia Inducible Factor (HIF) 1α transcription factor. The present investigation tested the therapeutic pot...

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Bibliographic Details
Main Authors: Molly E. Ogle, Xiaohuan Gu, Alyssa R. Espinera, Ling Wei
Format: Article
Language:English
Published: Elsevier 2012-02-01
Series:Neurobiology of Disease
Subjects:
Focal cerebral ischemia
Hypoxia inducible factor
Prolyl hydroxylase
preconditioning
Postconditioning
Dimethyloxaloylglycine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111003524

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http://www.sciencedirect.com/science/article/pii/S0969996111003524

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