The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

Summary: cGAS-STING signaling is essential for innate immunity. Its misregulation promotes cancer or autoimmune and autoinflammatory diseases, and it is imperative to identify effective lead compounds that specifically downregulate the pathway. We report here that astin C, a cyclopeptide isolated fr...

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Bibliographic Details
Main Authors: Senlin Li, Ze Hong, Zhe Wang, Fei Li, Jiahao Mei, Lulu Huang, Xiwen Lou, Simeng Zhao, Lihua Song, Wei Chen, Qiang Wang, Heng Liu, Yanni Cai, Huansha Yu, Huimin Xu, Guangzhi Zeng, Quanyi Wang, Juanjuan Zhu, Xing Liu, Ninghua Tan, Chen Wang
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718318886

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http://www.sciencedirect.com/science/article/pii/S2211124718318886

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