The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis

The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis

Naïve T cells (TN) constitutively recirculate through secondary lymphatic organs (SLOs), where they scan dendritic cells (DCs) for cognate peptide-loaded major histocompatibility complexes (pMHC). Continuous trafficking between SLOs not only enables rapid clonal selection but also ensures TN homeost...

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Bibliographic Details
Main Authors: Flavian Thelen, Stefanie Wissmann, Nora Ruef, Jens V. Stein
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
T cell trafficking
chemokine
signal transduction
Tec kinase
CCL21/CCR7 axis
intravital 2-photon microscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.716405/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.716405/full

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