The initial engraftment of tumor cells is critical for the future growth pattern: a mathematical study based on simulations and animal experiments

The initial engraftment of tumor cells is critical for the future growth pattern: a mathematical study based on simulations and animal experiments

Abstract Background Xenograft mouse tumor models are used to study mechanisms of tumor growth and metastasis formation and to investigate the efficacy of different therapeutic interventions. After injection the engrafted cells form a local tumor nodule. Following an initial lag period of several day...

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Bibliographic Details
Main Authors: Bertin Hoffmann, Tobias Lange, Vera Labitzky, Kristoffer Riecken, Andreas Wree, Udo Schumacher, Gero Wedemann
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Cancer
Subjects:
Tumor growth
Nonlinear systems
Parameter estimation
Nonlinear least squares
Gompertz model
Exponential model
Online Access:http://link.springer.com/article/10.1186/s12885-020-07015-9

Internet

http://link.springer.com/article/10.1186/s12885-020-07015-9

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