Pressure and Chemical Unfolding of an α-Helical Bundle Protein: The GH2 Domain of the Protein Adaptor GIPC1

Pressure and Chemical Unfolding of an α-Helical Bundle Protein: The GH2 Domain of the Protein Adaptor GIPC1

When combined with NMR spectroscopy, high hydrostatic pressure is an alternative perturbation method used to destabilize globular proteins that has proven to be particularly well suited for exploring the unfolding energy landscape of small single-domain proteins. To date, investigations of the unfol...

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Bibliographic Details
Main Authors: Cécile Dubois, Vicente J. Planelles-Herrero, Camille Tillatte-Tripodi, Stéphane Delbecq, Léa Mammri, Elena M. Sirkia, Virginie Ropars, Christian Roumestand, Philippe Barthe
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
protein folding
NMR
high hydrostatic pressure
thermodynamic stability
α-helical bundle
Online Access:https://www.mdpi.com/1422-0067/22/7/3597

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https://www.mdpi.com/1422-0067/22/7/3597

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