Common host variation drives malaria parasite fitness in healthy human red cells

Common host variation drives malaria parasite fitness in healthy human red cells

The replication of Plasmodium falciparum parasites within red blood cells (RBCs) causes severe disease in humans, especially in Africa. Deleterious alleles like hemoglobin S are well-known to confer strong resistance to malaria, but the effects of common RBC variation are largely undetermined. Here,...

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Bibliographic Details
Main Authors: Emily R Ebel, Frans A Kuypers, Carrie Lin, Dmitri A Petrov, Elizabeth S Egan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
malaria
Plasmodium falciparum
red blood cells
parasite fitness
natural variation
Online Access:https://elifesciences.org/articles/69808

Internet

https://elifesciences.org/articles/69808

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