The bacteriophage LUZ24 “Igy” peptide inhibits the Pseudomonas DNA gyrase

The bacteriophage LUZ24 “Igy” peptide inhibits the Pseudomonas DNA gyrase

Summary: The bacterial DNA gyrase complex (GyrA/GyrB) plays a crucial role during DNA replication and serves as a target for multiple antibiotics, including the fluoroquinolones. Despite it being a valuable antibiotics target, resistance emergence by pathogens including Pseudomonas aeruginosa are pr...

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Bibliographic Details
Main Authors: Jeroen De Smet, Jeroen Wagemans, Maarten Boon, Pieter-Jan Ceyssens, Marleen Voet, Jean-Paul Noben, Julia Andreeva, Dmitry Ghilarov, Konstantin Severinov, Rob Lavigne
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
DNA gyrase
Pseudomonas aeruginosa
ORFan
bacteriophage
drug discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721010019

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721010019

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