Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury
Background & Aims: Mitochondria are the major organelles for the formation of reactive oxygen species (ROS) in the cell, and mitochondrial dysfunction has been described as a key factor in the pathogenesis of cholestatic liver disease. The methylation-controlled J-protein (MCJ) is a mitochon...
Main Authors: | Paula Iruzubieta, Naroa Goikoetxea-Usandizaga, Lucía Barbier-Torres, Marina Serrano-Maciá, David Fernández-Ramos, Pablo Fernández-Tussy, Virginia Gutiérrez-de-Juan, Sofia Lachiondo-Ortega, Jorge Simon, Miren Bravo, Fernando Lopitz-Otsoa, Mercedes Robles, Carlos Ferre-Aracil, Marta Varela-Rey, Natalia Elguezabal, José Luis Calleja, Shelly C. Lu, Malgorzata Milkiewicz, Piotr Milkiewicz, Juan Anguita, María J. Monte, José J.G. Marin, Marcos López-Hoyos, Teresa C. Delgado, Mercedes Rincón, Javier Crespo, María Luz Martínez-Chantar |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-06-01
|
Series: | JHEP Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589555921000525 |
Similar Items
-
Glycolysis Induces MCJ Expression That Links T Cell Proliferation With Caspase-3 Activity and Death
by: Michael A. Secinaro, et al.
Published: (2019-03-01) -
Innate immune responses to B. burgdorferi mediated by JNK1 and the cochaperone, methylation controlled DNAJ (MCJ)
by: Izadi, Hooman
Published: (2011) -
Heterologous expression of AHL lactonase AiiK by Lactobacillus casei MCJΔ1 with great quorum quenching ability against Aeromonas hydrophila AH-1 and AH-4
by: Weiwei Dong, et al.
Published: (2020-10-01) -
The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury
by: Lucía Barbier-Torres, et al.
Published: (2017-12-01) -
Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
by: Lucía Barbier-Torres, et al.
Published: (2020-07-01)